Using the CHILD Cohort Study (www.childstudy.ca) as a research platform, the SyMBIOTA research program has sequenced the gut microbiota of over 1500 infants at 3 and 12 months of age using next generation Illumina 16S rRNA sequencing. To date it is the largest infant microbiome study in North America.
Current research projects include:
Characterizing microbiota profiles from fecal samples of CHILD study infants at birth, 3 months and 1 year of age, in order to describe the development of the gut microbiome during infancy.
Determining perinatal factors such as birth method, infant feeding type and antibiotic exposure, which shape infant gut microbiota at birth, age 3 months and 1 year, and its development over time.
Determining whether exposure-induced changes in gut microbiota due to infant antibiotic exposure, for example, are associated with: infant gut mucosal immunity (secretory IgA) and atopic disease (food allergy, atopic sensitization and dermatitis, recurrent wheeze) and childhood overweight/obesity.
Image by: Meghan Azad